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Pombe's thirteen - control of fission yeast cell division by the septation initiation network.

  • Simanis V École Polytechnique Fédérale de Lausanne School of Life Sciences (EPFL-SV), Swiss Institute For Experimental Cancer Research (ISREC), UPSIM, SV2.1830, Station 19, CH-1015 Lausanne, Switzerland viesturs.simanis@epfl.ch.
  • 2015-02-19
Published in:
  • Journal of cell science. - 2015
Cell division
Cytokinesis
Kinase
Phosphatase
Signalling
Yeast
Cell Cycle Checkpoints
Cytokinesis
Meiosis
Mitosis
Schizosaccharomyces
Signal Transduction
Spindle Pole Bodies
English The septation initiation network (SIN) regulates aspects of cell growth and division in Schizosaccharomyces pombe and is essential for cytokinesis. Insufficient signalling results in improper assembly of the contractile ring and failure of cytokinesis, generating multinucleated cells, whereas too much SIN signalling uncouples cytokinesis from the rest of the cell cycle. SIN signalling is therefore tightly controlled to coordinate cytokinesis with chromosome segregation. Signalling originates from the cytoplasmic face of the spindle pole body (SPB), and asymmetric localisation of some SIN proteins to one of the two SPBs during mitosis is important for regulation of the SIN. Recent studies have identified in vivo substrates of the SIN, which include components involved in mitotic control, those of the contractile ring and elements of the signalling pathway regulating polarised growth. The SIN is also required for spore formation following meiosis. This has provided insights into how the SIN performs its diverse functions in the cell cycle and shed new light on its regulation.
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.rero.ch/global/documents/97209
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