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Automated determination of bone age from hand X-rays at the end of puberty and its applicability for age estimation.
Journal article

Automated determination of bone age from hand X-rays at the end of puberty and its applicability for age estimation.

  • Thodberg HH Visiana, Søllerødvej 57C, 2840, Holte, Denmark. thodberg@visiana.com.
  • van Rijn RR Academic Medical Center, Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
  • Jenni OG Child Development Center, University Children's Hospital Zürich, Steinwiesstrasse 75, 8032, Zürich, Switzerland.
  • Martin DD Tubingen University Children's Hospital, Hoppe-Seyler-Strasse 1, 72076 Tübingen, and Filderklinik, Im Haberschlai 7, 70794, Filderstadt, Germany.
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  • 2016-10-21
Published in:
  • International journal of legal medicine. - 2017
Age assessment
Asylum seekers
Bayes
Bone age
Hand radiographs
Adolescent
Age Determination by Skeleton
Female
Forensic Anthropology
Hand Bones
Humans
Male
Puberty
Radius
Ulna
Young Adult
English The BoneXpert method for automated determination of bone age from hand X-rays was introduced in 2009, covering the Greulich-Pyle bone age ranges up to 17 years for boys and 15 years for girls. This paper presents an extension of the method up to bone age 19 years for boys and 18 years for girls. The extension was developed based on images from the First Zurich Longitudinal Study of 231 healthy children born in 1954-1956 and followed with annual X-rays of both hands until adulthood. The method was validated on two cross-sectional studies of healthy children from Rotterdam and Los Angeles. We found root mean square deviations from manual rating of 0.69 and 0.45 years in these two studies for boys in the bone age range 17-19 years. For girls, the deviations were 0.75 and 0.59 years, respectively, in the bone age range 15-18 years. It is shown how the automated bone age method can be applied to infer the age probability distribution for healthy Caucasian European males. Considering a population with age 15.0-21.0 years, the method can be used to decide whether the subject is above 18 years with a false positive rate (children classified as adults) of 10 % (95% confidence interval = 7-13%) and a false negative rate of 30 % (adults classified as children). To apply this method in other ethnicities will require a study of the average of "bone age - age" at the end of puberty, i.e. how much this population is shifted relative to the Greulich-Pyle standard.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.rero.ch/global/documents/88279
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