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Journal article

Hypocretin (orexin) deficiency predicts severe objective excessive daytime sleepiness in narcolepsy with cataplexy.

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  • 2006-02-18
Published in:
  • Journal of neurology, neurosurgery, and psychiatry. - 2006
Adolescent
Adult
Cataplexy
Disorders of Excessive Somnolence
Female
Humans
Intracellular Signaling Peptides and Proteins
Male
Middle Aged
Narcolepsy
Neuropeptides
Orexins
Polysomnography
Predictive Value of Tests
Prognosis
Sleep, REM
English Cerebrospinal fluid (CSF) hypocretin-1 deficiency is associated with definite ("clear cut") cataplexy in patients with narcolepsy. The relationship between CSF hypocretin-1 levels and other narcoleptic symptoms (including excessive daytime sleepiness, EDS) is not properly understood. In a consecutive series of 18 subjects with narcolepsy and definite cataplexy, patients with undetectable CSF hypocretin-1 (n = 12) were found to have significantly lower mean sleep latencies (p = 0.045) and a higher frequency of sleep onset REM periods (SOREMPs, p = 0.025) on multiple sleep latency test than patients (n = 6) with detectable levels. Conversely, Epworth sleepiness scale scores, the frequency of hallucinations/sleep paralysis, and the frequency and severity of cataplexy were similar in both groups. These results suggest that hypocretin deficiency identifies a homogenous group of patients with narcolepsy characterised by the presence of definite cataplexy, severe EDS, and frequent SOREMPs.
Language
  • English
Open access status
green
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Persistent URL
https://sonar.rero.ch/global/documents/85069
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