Sugar modification as a means to increase the biological performance of oligonucleotides.
- Leumann CJ Department of Chemistry & Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland.
- 2006-12-08
Published in:
- Nucleic acids symposium series (2004). - 2006
English
Modification of the ribose unit in DNA and RNA profoundly influences the self-rcognition and the biological properties of the nucleic acids. Conformational restriction of the ribose units, as in LNA and tricyclo-DNA, has been identified as a powerful tool to increase DNA and RNA affinity as well as biological stability and antisense properties. Apart from that sugar modified DNA analogues, as homo-DNA, have shown to be orthogonal base-pairing systems which by virtue of non-crosscommunicating with the natural nucleic acids open novel applications in biotechnology.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1093/nass/nrl167
- PMID 17150814
- Persistent URL
- https://sonar.rero.ch/global/documents/71126
Statistics
Document views: 16
File downloads:
- Full-text: 0