Journal article
TERRA: Long Noncoding RNA at Eukaryotic Telomeres.
- Arora R Institute of Biochemistry, ETHZ-Eidgenössische Technische Hochschule Zürich, CH-8093, Zürich, Switzerland.
- Brun CM
- Azzalin CM
- 2011-02-03
Published in:
- Progress in molecular and subcellular biology. - 2011
English
Telomeres protect the ends of linear eukaryotic chromosomes from being recognized as DNA double-stranded breaks, thereby maintaining the stability of our genome. The highly heterochromatic nature of telomeres had, for a long time, reinforced the idea that telomeres were transcriptionally silent. Since a few years, however, we know that DNA-dependent RNA polymerase II transcribes telomeric DNA into TElomeric Repeat-containing RNA (TERRA) molecules in a large variety of eukaryotes. In this chapter, we summarize the current knowledge of telomere structure and function and extensively review data accumulated on TERRA biogenesis and regulation. We also discuss putative functions of TERRA in preserving telomere stability and propose future directions for research encompassing this novel and exciting aspect of telomere biology.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1007/978-3-642-16502-3_4
- PMID 21287134
- Persistent URL
- https://sonar.rero.ch/global/documents/67936
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