Journal article
An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes.
- Patra M Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. gilles.gasser@chem.uzh.ch.
- Bauman A
- Mari C
- Fischer CA
- Blacque O
- Häussinger D
- Gasser G
- Mindt TL
- 2014-08-19
Published in:
- Chemical communications (Cambridge, England). - 2014
Cell Line, Tumor
Chelating Agents
Coordination Complexes
Crystallography, X-Ray
Deferoxamine
Humans
Molecular Conformation
Molecular Probes
Peptides
Radiopharmaceuticals
Zirconium
English
(89)Zr-based imaging agents hold great promise as novel radio-tracers in nuclear medicine. However, insufficient stability of currently used radiometal complexes in vivo is a safety concern for clinical applications. We herein report the first octadentate bifunctional chelating agent for the development of (89)Zr-labelled (bio)conjugates with improved stability.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1039/c4cc05558f
- PMID 25132321
- Persistent URL
- https://sonar.rero.ch/global/documents/66267
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