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The Prospect and Challenges to the Flow of Liquid Biopsy in Africa.

  • Temilola DO International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa.
  • Wium M International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa.
  • Coulidiati TH International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa.
  • Adeola HA Division of Dermatology, Department of Medicine, Faculty of Health Sciences and Groote Schuur Hospital, University of Cape Town, Cape Town 7925, South Africa.
  • Carbone GM Institute of Oncology Research, Università della Svizzera Italiana, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland.
  • Catapano CV Institute of Oncology Research, Università della Svizzera Italiana, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland.
  • Zerbini LF International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa. luiz.zerbini@icgeb.org.
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  • 2019-08-14
Published in:
  • Cells. - 2019
Africa
cancer
cell-free DNA
circulating RNA
circulating tumor cell
liquid biopsy
non-invasive
Africa
Biomarkers, Tumor
Humans
Liquid Biopsy
Neoplasms
Neoplastic Cells, Circulating
English Liquid biopsy technologies have the potential to transform cancer patient management as it offers non-invasive diagnosis and real-time monitoring of disease progression and treatment responses. The use of liquid biopsy for non-invasive cancer diagnosis can have pivotal importance for the African continent where access to medical infrastructures is limited, as it eliminates the need for surgical biopsies. To apply liquid biopsy technologies in the African setting, the influence of environmental and population genetic factors must be known. In this review, we discuss the use of circulating tumor cells, cell-free nucleic acids, extracellular vesicles, protein, and other biomolecules in liquid biopsy technology for cancer management with special focus on African studies. We discussed the prospect, barriers, and other aspects that pose challenges to the use of liquid biopsy in the African continent.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.rero.ch/global/documents/62681
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