Journal article
DNA analogues: from supramolecular principles to biological properties.
- Leumann CJ Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012, Bern, Switzerland. leumann@ioc.unibe.ch
- 2002-02-12
Published in:
- Bioorganic & medicinal chemistry. - 2002
English
Mainly driven by the needs of antisense research, a large number of oligonucleotide analogues have been prepared and evaluated over the last 15 years. Besides minor structural modifications of the building blocks of DNA and RNA itself, a considerable effort has been devoted to the de novo design of nucleoside analogues with improved binding properties. A particularly successful concept turned out to be that of conformational restriction. This review focuses on recent advances in this area and tries to summarize scope and limitations of this design principle.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/s0968-0896(01)00348-0
- PMID 11836090
- Persistent URL
- https://sonar.rero.ch/global/documents/55761
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