Journal article
Not as simple as just punching a hole.
- Fivaz M Department of Biochemistry, Faculty of Sciences, University of Geneva, 30 quai E. Ansermet, 1211 Geneva 4, Switzerland.
- Abrami L
- Tsitrin Y
- van der Goot FG
- 2001-10-12
Published in:
- Toxicon : official journal of the International Society on Toxinology. - 2001
Aeromonas
Animals
Bacterial Toxins
Cell Death
Humans
Models, Molecular
Pore Forming Cytotoxic Proteins
Structure-Activity Relationship
English
Like a variety of other pathogenic bacteria, Aeromonas hydrophila secretes a pore-forming toxin that contribute to its virulence. The last decade has not only increased our knowledge about the structure of this toxin, called aerolysin, but has also shed light on how it interacts with its target cell and how the cell reacts to this stress. Whereas pore-forming toxins are generally thought to lead to brutal death by osmotic lysis of the cell, based on what is observed for erythrocytes, recent studies have started to reveal far more complicated pathways leading to death of nucleated mammalian cells.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/s0041-0101(01)00151-9
- PMID 11595627
- Persistent URL
- https://sonar.rero.ch/global/documents/5407
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