Context Matters: RNF168 Connects with PALB2 to Rewire Homologous Recombination in BRCA1 Haploinsufficiency.
- Porro A Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
- Sartori AA Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. Electronic address: sartori@imcr.uzh.ch.
- 2019-03-23
Published in:
- Molecular cell. - 2019
English
In this issue of Molecular Cell, Zong et al. (2019) reveal RNF168-driven chromatin ubiquitylation as a key back-up mechanism to sustain homologous recombination (HR) independently of BRCA1. These findings provide new clues to carcinogenesis and cancer therapy in BRCA1 heterozygous mutation carriers.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1016/j.molcel.2019.03.005
- PMID 30901561
- Persistent URL
- https://sonar.rero.ch/global/documents/47496
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