Back
Full-text
Journal article

Time-resolved singlet-oxygen luminescence detection with an efficient and practical semiconductor single-photon detector.

  • Boso G Group of Applied Physics, University of Geneva, Chemin de Pinchat 22, Genève 4, CH-1211, Switzerland.
  • Ke D School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, Genève 4, CH-1211, Switzerland.
  • Korzh B Group of Applied Physics, University of Geneva, Chemin de Pinchat 22, Genève 4, CH-1211, Switzerland.
  • Bouilloux J School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, Genève 4, CH-1211, Switzerland.
  • Lange N School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, Genève 4, CH-1211, Switzerland.
  • Zbinden H Group of Applied Physics, University of Geneva, Chemin de Pinchat 22, Genève 4, CH-1211, Switzerland.
Show more…
  • 2016-01-29
Published in:
  • Biomedical optics express. - 2016
(030.5260) Photon counting
(170.3880) Medical and biological imaging
(170.5180) Photodynamic therapy
(170.6280) Spectroscopy, fluorescence and luminescence
(170.6920) Time-resolved imaging
(230.5160) Photodetectors
(250.5230) Photoluminescence
(270.5570) Quantum detectors
(350.5130) Photochemistry
English In clinical applications, such as PhotoDynamic Therapy, direct singlet-oxygen detection through its luminescence in the near-infrared range (1270 nm) has been a challenging task due to its low emission probability and the lack of suitable single-photon detectors. Here, we propose a practical setup based on a negative-feedback avalanche diode detector that is a viable alternative to the current state-of-the art for different clinical scenarios, especially where geometric collection efficiency is limited (e.g. fiber-based systems, confocal microscopy, scanning systems etc.). The proposed setup is characterized with Rose Bengal as a standard photosensitizer and it is used to measure the singlet-oxygen quantum yield of a new set of photosensitizers for site-selective photodynamic therapy.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.rero.ch/global/documents/46617
Statistics
Document views: 28 File downloads:
  • fulltext.pdf: 0