Journal article
Effect of ritanserin on sleep stages and sleep EEG in the rat.
- Borbély AA Institute of Pharmacology, University of Zürich, Switzerland.
- Trachsel L
- Tobler I
- 1988-11-01
Published in:
- European journal of pharmacology. - 1988
Animals
Dose-Response Relationship, Drug
Electroencephalography
Male
Piperidines
Rats
Rats, Inbred Strains
Ritanserin
Sleep Stages
English
Ritanserin (1.0 and 2.5 mg/kg i.p.) was administered to rats before the start, of the light period, and sleep was recorded during the subsequent 12 h. The higher dose reduced sleep in the first 3 h. Both doses caused a more prolonged suppression of REM sleep. Spectral analysis of the EEG in non-REM sleep showed an increase of power density in the low frequency range (1.5-6 Hz) and a depression in the high frequency range (8-25 Hz). Since these changes differ from those previously observed after sleep deprivation, it is premature to conclude that the drug induces a physiological sleep intensification.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/0014-2999(88)90332-9
- PMID 3149244
- Persistent URL
- https://sonar.rero.ch/global/documents/3049
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