Journal article

Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

  • Van Dijck P VIB-KU Leuven Center for Microbiology, Leuven, Belgium.
  • Sjollema J University of Groningen, University Medical Center Groningen, Department of BioMedical Engineering, Groningen, The Netherlands.
  • Cammue BP Centre for Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
  • Lagrou K Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
  • Berman J School of Molecular Cell Biology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel.
  • d'Enfert C Institut Pasteur, INRA, Unité Biologie et Pathogénicité Fongiques, Paris, France.
  • Andes DR Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Arendrup MC Unit of Mycology, Statens Serum Institut, Copenhagen, Denmark.
  • Brakhage AA Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute (HKI), Dept. Microbiology and Molecular Biology, Friedrich Schiller University Jena, Institute of Microbiology, Jena, Germany.
  • Calderone R Department of Microbiology & Immunology, Georgetown University Medical Center, Washington DC, USA.
  • Cantón E Severe Infection Research Group: Medical Research Institute La Fe (IISLaFe), Valencia, Spain.
  • Coenye T Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.
  • Cos P Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Belgium.
  • Cowen LE Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  • Edgerton M Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, NY USA.
  • Espinel-Ingroff A VCU Medical Center, Richmond, VA, USA.
  • Filler SG Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Ghannoum M Center for Medical Mycology, Department of Dermatology, University Hospitals Cleveland Medical Center and Case Western Re-serve University, Cleveland, OH, USA.
  • Gow NAR MRC Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • Haas H Biocenter - Division of Molecular Biology, Medical University Innsbruck, Innsbruck, Austria.
  • Jabra-Rizk MA Department of Oncology and Diagnostic Sciences, School of Dentistry; Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, USA.
  • Johnson EM National Infection Service, Public Health England, Mycology Reference Laboratory, Bristol, UK.
  • Lockhart SR Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Lopez-Ribot JL Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Maertens J Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium and Clinical Department of Haematology, UZ Leuven, Leuven, Belgium.
  • Munro CA MRC Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • Nett JE University of Wisconsin-Madison, Departments of Medicine and Medical Microbiology & Immunology, Madison, WI, USA.
  • Nobile CJ Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, Merced, USA.
  • Pfaller MA Departments of Pathology and Epidemiology, University of Iowa, Iowa, USA.
  • Ramage G ESCMID Study Group for Biofilms, Switzerland.
  • Sanglard D Institute of Microbiology, University of Lausanne and University Hospital, CH-1011 Lausanne.
  • Sanguinetti M Institute of Microbiology, Università Cattolica del Sacro Cuore, IRCCS-Fondazione Policlinico "Agostino Gemelli", Rome, Italy.
  • Spriet I Pharmacy Dpt, University Hospitals Leuven and Clinical Pharmacology and Pharmacotherapy, Dpt. of Pharmaceutical and Pharma-cological Sciences, KU Leuven, Belgium.
  • Verweij PE Center of Expertise in Mycology Radboudumc/CWZ, Radboud University Medical Center, Nijmegen, the Netherlands (omit "Nijmegen" in Radboud University Medical Center).
  • Warris A MRC Centre for Medical Mycology, Aberdeen Fungal Group, University of Aberdeen, Foresterhill, Aberdeen, UK.
  • Wauters J KU Leuven-University of Leuven, University Hospitals Leuven, Department of General Internal Medicine, Herestraat 49, B-3000 Leuven, Belgium.
  • Yeaman MR Geffen School of Medicine at the University of California, Los Angeles, Divisions of Molecular Medicine & Infectious Diseases, Har-bor-UCLA Medical Center, LABioMed at Harbor-UCLA Medical Center.
  • Zaat SAJ Department of Medical Microbiology, Amsterdam Infection and Immunity Institute, Academic Medical Center, University of Am-sterdam, Netherlands.
  • Thevissen K Centre for Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
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  • 2018-07-12
Published in:
  • Microbial cell (Graz, Austria). - 2018
English Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance to the commonly used antifungal agents. Therefore, the availability of accurate susceptibility testing methods for determining antifungal resistance, as well as discovery of novel antifungal and antibiofilm agents, are key priorities in medical mycology research. To direct advancements in this field, here we present an overview of the methods currently available for determining (i) the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations; (ii) the in vivo efficacy of antifungal and antibiofilm compounds and compound combinations; and (iii) the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.rero.ch/global/documents/295798
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