Journal article
The alpha 1a and alpha 1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action.
- Cotecchia S Institut de Pharmacologie et Toxicologie, Université de Lausanne, Faculté de Médecine, Switzerland. susanna.cotecchia@ipharm.unil.ch
- Rossier O
- Fanelli F
- Leonardi A
- De Benedetti PG
- 2000-05-17
Published in:
- Pharmaceutica acta Helvetiae. - 2000
English
In this chapter we summarize some aspects of the structure-functional relationship of the alpha 1a and alpha 1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the alpha 1a and alpha 1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/s0031-6865(99)00031-x
- PMID 10812955
- Persistent URL
- https://sonar.rero.ch/global/documents/290188
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