Journal article
Levocetirizine better protects than desloratadine in a nasal provocation with allergen.
- Deruaz C Division of Allergy and Immunology, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon, 1011 Lausanne, Switzerland.
- Leimgruber A
- Berney M
- Pradervand E
- Spertini F
- 2004-04-22
Published in:
- The Journal of allergy and clinical immunology. - 2004
Adult
Albumins
Allergens
Biomarkers
Cetirizine
Cross-Over Studies
Differential Threshold
Double-Blind Method
Female
Histamine H1 Antagonists, Non-Sedating
Humans
Hypersensitivity
Loratadine
Male
Nasal Lavage Fluid
Nasal Provocation Tests
Piperazines
Poaceae
Pollen
Treatment Outcome
English
BACKGROUND
Direct comparisons of antihistamines are rare but very much needed. Newly available antihistamine preparations, levocetirizine, the R-enantiomer of racemate cetirizine, and desloratadine, an active metabolite of loratadine, have been recently released for allergic rhinitis.
OBJECTIVE
We sought to compare levocetirizine and desloratadine in a nasal provocation test (NPT) with grass pollen.
METHODS
Twenty-four volunteers with grass pollen allergy and a history of rhinitis were enrolled in a double-blind, placebo-controlled, crossover study. Three NPTs were performed in a dose-escalating manner during the out-of-season period 4 hours after a single dose of levocetirizine (5 mg), desloratadine (5 mg), or placebo.
RESULTS
CONCLUSIONS
This study demonstrates a better overall protection of a single dose of levocetirizine compared with desloratadine in an NPT with grass pollen allergen. In contrast to late-phase inflammatory markers, which were unaffected, extravascular leakage of the early-phase marker albumin was significantly limited by levocetirizine.
Direct comparisons of antihistamines are rare but very much needed. Newly available antihistamine preparations, levocetirizine, the R-enantiomer of racemate cetirizine, and desloratadine, an active metabolite of loratadine, have been recently released for allergic rhinitis.
OBJECTIVE
We sought to compare levocetirizine and desloratadine in a nasal provocation test (NPT) with grass pollen.
METHODS
Twenty-four volunteers with grass pollen allergy and a history of rhinitis were enrolled in a double-blind, placebo-controlled, crossover study. Three NPTs were performed in a dose-escalating manner during the out-of-season period 4 hours after a single dose of levocetirizine (5 mg), desloratadine (5 mg), or placebo.
RESULTS
CONCLUSIONS
This study demonstrates a better overall protection of a single dose of levocetirizine compared with desloratadine in an NPT with grass pollen allergen. In contrast to late-phase inflammatory markers, which were unaffected, extravascular leakage of the early-phase marker albumin was significantly limited by levocetirizine.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.jaci.2004.01.773
- PMID 15100671
- Persistent URL
- https://sonar.rero.ch/global/documents/282881
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