Journal article
Interleukin-8, a chemotactic and inflammatory cytokine.
- Baggiolini M Theodor-Kocher Institute, University of Bern, Switzerland.
- Clark-Lewis I
- 1992-07-27
Published in:
- FEBS letters. - 1992
Amino Acid Sequence
Animals
Chemotaxis, Leukocyte
Humans
Inflammation
Interleukin-8
Molecular Sequence Data
English
Interleukin-8 (IL-8) belongs to a family of small, structurally related cytokines similar to platelet factor 4. It is produced by phagocytes and mesenchymal cells exposed to inflammatory stimuli (e.g., interleukin-1 or tumor necrosis factor) and activates neutrophils inducing chemotaxis, exocytosis and the respiratory burst. In vivo, IL-8 elicits a massive neutrophil accumulation at the site of injection. Five neutrophil-activating cytokines similar to IL-8 in structure and function have been identified recently. IL-8 and the related cytokines are produced in several tissues upon infection, inflammation, ischemia, trauma etc., and are thought to be the main cause of local neutrophil accumulation.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/0014-5793(92)80909-z
- PMID 1639201
- Persistent URL
- https://sonar.rero.ch/global/documents/260340
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