SARS-CoV-2 receptor ACE2 gene expression in small intestine correlates with age.
- Vuille-Dit-Bille RN Department of Pediatric Surgery, University Children's Hospital of Basel, Spitalstrasse 33, 4056, Basel, Switzerland. rnvuille@gmail.com.
- Liechty KW Department of Pediatric Surgery, University Children's Hospital of Colorado, Aurora, USA.
- Verrey F Institute of Physiology, University of Zurich, Zurich, Switzerland.
- Guglielmetti LC Department of Visceral and Thoracic Surgery, Cantonal Hospital of Winterthur, Winterthur, Switzerland.
- 2020-07-07
Published in:
- Amino acids. - 2020
ACE2
Age
COVID-19
SARS-CoV-2
Adult
Age Factors
Aged
Betacoronavirus
Female
Gene Expression
Humans
Intestine, Small
Male
Middle Aged
Peptidyl-Dipeptidase A
RNA, Messenger
Receptors, Virus
Young Adult
English
Gastrointestinal symptoms are common in COVID-19 patients, especially in younger patients. Our hypothesis was that intestinal SARS-CoV-2 receptor ACE2 expression depends on patients' age. We examined duodenal biopsies from 43 healthy human adults. ACE2 gene expression was directly correlated with age (Spearman's r = 0.317, p = 0.039). With each year, duodenal ACE2 expression increased by 0.083 RU. The higher intestinal ACE2 mRNA expression in older patients may impact on their susceptibility to develop intestinal symptoms.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1007/s00726-020-02870-z
- PMID 32627059
- Persistent URL
- https://sonar.rero.ch/global/documents/258936
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