Journal article
Transepithelial transport and mucosal defence II: secretion of IgA.
- Kraehenbuhl JP Swiss Institute for Experimental Cancer Research and Institute of Biochemistry, University of Lausanne, Switzerland.
- Neutra MR
- 1992-06-01
Published in:
- Trends in cell biology. - 1992
English
In this second article on mucosal defence and transepithelial transport, Jean-Pierre Kraehenbuhl and Marian Neutra discuss the part played by a special class of antibody, polymeric IgA, in the protection of mucosal surfaces lining the digestive, respiratory and genital tracts, and the implications for mucosal vaccines. Polymeric IgA crosslinks luminal antigens or pathogens, thus preventing their interaction with epithelial cells. Following stimulation by antigen in the organized mucosal lymphoid tissue, effector B lymphocytes enter the circulation and migrate to distant mucosal or glandular sites, where they differentiate into polymeric-IgA-producing plasma cells. These antibodies reach the environment by transport across the epithelial cells of mucosal and glandular tissues.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/0962-8924(92)90036-m
- PMID 14731986
- Persistent URL
- https://sonar.rero.ch/global/documents/250985
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