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Journal article

CSF prostaglandin D synthase is reduced in excessive daytime sleepiness.

  • Bassetti CL Department of Neurology, Universitätsspital Zürich, Frauenklinikstrasse 26, 8091 Zürich, Switzerland. claudio.bassetti@usz.ch
  • Hersberger M
  • Baumann CR
  • 2006-04-07
Published in:
  • Journal of neurology. - 2006
Adult
Aged
Case-Control Studies
Cataplexy
Chronic Disease
Female
Humans
Intramolecular Oxidoreductases
Lipocalins
Male
Middle Aged
Narcolepsy
Polysomnography
Sleep Deprivation
Sleep Stages
English Lipocalin-type prostaglandin D synthase (L-PGDS) is a brain enzyme, which produces prostaglandin D(2), a substance with endogenous somnogenic effects. Using a standardized protocol for immunonephelometric determination of cerebrospinal fluid (CSF) L-PGDS levels, we show that CSF L-PGDS levels are significantly lower in 34 patients with excessive daytime sleepiness when compared with levels in 22 healthy controls. Thus, L-PGDS may represent the first neurochemical measure of excessive daytime sleepiness.
Language
  • English
Open access status
green
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Persistent URL
https://sonar.rero.ch/global/documents/243919
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