Journal article
The catalytic mechanism of sulfoxide synthases.
- Stampfli AR Department for Chemistry, University of Basel, BPR 1096, Mattenstrasse 24a, Basel, Switzerland.
- Seebeck FP Department for Chemistry, University of Basel, BPR 1096, Mattenstrasse 24a, Basel, Switzerland. Electronic address: florian.seebeck@unibas.ch.
- 2020-07-30
Published in:
- Current opinion in chemical biology. - 2020
English
Sulfoxide synthases are non-heme iron enzymes that catalyze oxidative carbonsulfur bond formation in the biosynthesis of thiohistidines such as ergothioneine and ovothiol. The catalytic mechanism of these enzymes has been studied by protein crystallography, steady-state kinetics, non-natural amino acid incorporation and computational modeling. This review discusses the current status of this research and also highlights similarities between the CS bond forming activity of sulfoxide synthases with that of synthetic coordination compounds.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1016/j.cbpa.2020.06.007
- PMID 32726707
- Persistent URL
- https://sonar.rero.ch/global/documents/242129
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