Journal article
The impact of frozen sections on final surgical margins in squamous cell carcinoma of the oral cavity and lips: a retrospective analysis over an 11 years period.
- Gerber S Department of Craniomaxillofacial and Oral Surgery, University Hospital Zurich, Switzerland. gerber.stefan@hotmail.com
- Gengler C
- Grätz KW
- Kruse AL
- 2012-01-03
Published in:
- Head & neck oncology. - 2011
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
Female
Frozen Sections
Humans
Lip
Male
Middle Aged
Mouth Neoplasms
Neoplasm Staging
Retrospective Studies
English
BACKGROUND
Taking intraoperative frozen sections (FS) is a widely used procedure in oncologic surgery. However so far no evidence of an association of FS analysis and premalignant changes in the surgical margin exists. Therefore, the aim of this study was to evaluate the impact of FS on different categories of the final margins of squamous cell carcinoma (SCC) of the oral cavity and lips.
METHODS
FS, pT-stage, grading, and tumor localization of 178 patients with SCC of the oral cavity and lips were compared by uni- and multivariate analysis in patients with positive, dysplastic and negative surgical margin status.
RESULTS
Performed on 111 patients (62.4%), intraoperative FS did not have any statistically significant influence on final margin status, independent of whether it was positive (p = 0.40), dysplastic (p = 0.70), or negative (p = 0.70). Positive surgical margins in permanent sections were significantly associated with pT4-tumors (OR 5.61, p = 0.001). The chance for negative margins in permanent sections was significantly higher in tumors located in the tongue (OR 4.70, p = 0.01).
CONCLUSIONS
Our data suggests that intraoperative FS in SCC can be useful in selected cases. However it is not advisable as a routine approach.
Taking intraoperative frozen sections (FS) is a widely used procedure in oncologic surgery. However so far no evidence of an association of FS analysis and premalignant changes in the surgical margin exists. Therefore, the aim of this study was to evaluate the impact of FS on different categories of the final margins of squamous cell carcinoma (SCC) of the oral cavity and lips.
METHODS
FS, pT-stage, grading, and tumor localization of 178 patients with SCC of the oral cavity and lips were compared by uni- and multivariate analysis in patients with positive, dysplastic and negative surgical margin status.
RESULTS
Performed on 111 patients (62.4%), intraoperative FS did not have any statistically significant influence on final margin status, independent of whether it was positive (p = 0.40), dysplastic (p = 0.70), or negative (p = 0.70). Positive surgical margins in permanent sections were significantly associated with pT4-tumors (OR 5.61, p = 0.001). The chance for negative margins in permanent sections was significantly higher in tumors located in the tongue (OR 4.70, p = 0.01).
CONCLUSIONS
Our data suggests that intraoperative FS in SCC can be useful in selected cases. However it is not advisable as a routine approach.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1186/1758-3284-3-56
- PMID 22208692
- Persistent URL
- https://sonar.rero.ch/global/documents/228736
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