Journal article
Asymmetric synthesis of 3,3-diarylpropanals with chiral diene-rhodium catalysts.
- Paquin JF Laboratorium für Organische Chemie, ETH Hönggerberg, CH-8093 Zürich, Switzerland.
- Defieber C
- Stephenson CR
- Carreira EM
- 2005-08-04
Published in:
- Journal of the American Chemical Society. - 2005
English
A general route to enantioenriched 3,3-diarylpropanals is presented. These useful building blocks are prepared via an asymmetric rhodium-catalyzed conjugate addition of arylboronic acids to cinnamaldehyde derivatives in the presence of chiral dienes. The addition of both electron-poor as well as electron-rich boronic acids proceeds smoothly with various enals in 63-90% yield with high enantioselectivities (89-93% ee).
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1021/ja053270w
- PMID 16076189
- Persistent URL
- https://sonar.rero.ch/global/documents/207853
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