Journal article
Dietary Inflammatory Index (DII®) and Lung Function in Adults from Ten European Countries – Evidence from the GA2LEN Follow-Up Survey
- Mendes, Francisca de Castro Visiting Scholar, The Johns Hopkins Bloomberg of Public Health; PhD Student, Serviço de Imunologia Básica e Clínica, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto; EPI Unit - Instituto de Saúde Pública, Universidade do Porto
- Thawer, Sumaiyya Swiss Tropical Institute of Public Health, University of Basel, Basel, Switzerland
- Shivappa, Nitin Cancer Prevention and Control Program, University of South Carolina; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina; Connecting Health Innovations LLC
- Hebert, James R Director, Cancer Prevention and Control Program, University of South Carolina; Health Sciences Distinguished Professor, Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina; President and Scientific Director, Connecting Health Innovations LLC
- Burney, Peter G J National Heart and Lung Institute, Imperial College London, UK
- Garcia-Larsen, Vanessa Program in Human Nutrition, Department of International Health, The Johns Hopkins Bloomberg School of Public Health
- 2020-5-29
Published in:
- Current Developments in Nutrition. - Oxford University Press (OUP). - 2020, vol. 4, no. Supplement_2, p. 1393-1393
English
Abstract
Objectives
To investigate the association between Dietary Inflammatory Index (DII®) and lung function in European adults.
Methods
The study sample was drawn from the Global Allergy and Asthma Network of Excellence (GA2LEN) screening survey, in which 55,000 adults aged 15 to 75 years answered a postal questionnaire on respiratory symptoms. A stratified random sample was obtained for follow-up. A cross-sectional study was conducted in this sample (n = 3241), which included ascertainment of dietary intake and measures of lung function. Participants completed the internationally validated GA2LEN food frequency questionnaire (FFQ), which enquired about usual intake of 245 food items. The dietary inflammatory index (DII®) was derived to ascertain the inflammatory potential of the diet (minimum and maximum reference range −8.87 to 7.98; i.e., the higher the score the more pro-inflammatory the diet). Participants performed post-bronchodilator spirometry, from which forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV1) and FVC (FEV1/FVC), FVC below lower limit of normal (FVC < LLN; (restriction)) and FEV1/FVC < LLN (airway obstruction) were calculated. Exposures and lung function outcomes were weighted to obtain estimated population parameters. Potential confounders included age, sex, height, body mass index, smoking status, country, education and employment. Adjusted regressions were used to investigate the associations between DII and respiratory outcomes.
Results
The mean age of participants was 48 years (SD ± 15.1), and the median DII was −1.53 (IQR difference 3.5). In the fully adjusted models, a one-unit increase in DII score was statistically significantly associated with a lower FEV1/FVC (β-coefficient −0.46, 95% CI −0.80, −0.12; P-value = 0.008) and with airway obstruction (odds ratio [OR] 1.17, 95% CI 1.03, 1.34; P-value = 0.018]. There was no association with the other lung function outcomes.
Conclusions
A more pro-inflammatory diet was associated with greater airway obstruction amongst European adults.
Funding Sources
FCM is funded by The Fulbright Commission and by the Fundação para a Ciência e Tecnologia (SFRH/BD/144,563/2019). This work was conducted as part of The GA2LEN Working Group WP1.2 Epi & Clinical Studies. GA2LEN was funded by the EU Framework Programme for Research, contract No FOOD-CT-2004–506,378.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1093/cdn/nzaa061_021
- ISSN 2475-2991
- Persistent URL
- https://sonar.rero.ch/global/documents/202014
Statistics
Document views: 21
File downloads: