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Baff Binds to the Tumor Necrosis Factor Receptor–Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the Peripheral B Cell Population

  • Thompson, Jeffrey S. Department of Molecular Genetics, Biogen, Incorporated, Cambridge, Massachusetts 02142
  • Schneider, Pascal Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
  • Kalled, Susan L. Department of Immunology and Inflammation, Biogen, Incorporated, Cambridge, Massachusetts 02142
  • Wang, LiChun Department of Immunology and Inflammation, Biogen, Incorporated, Cambridge, Massachusetts 02142
  • Lefevre, Eric A. Institut National de la Santé et de la Recherche Médicale U131, 92140 Clamart, France
  • Cachero, Teresa G. Department of Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
  • MacKay, Fabienne Garvan Institute of Medical Research, St. Vincent's Hospital, Darlinghurst NSW 2010, Australia
  • Bixler, Sarah A. Department of Molecular Genetics, Biogen, Incorporated, Cambridge, Massachusetts 02142
  • Zafari, Mohammad Department of Immunology and Inflammation, Biogen, Incorporated, Cambridge, Massachusetts 02142
  • Liu, Zhong-Ying Department of Immunology and Inflammation, Biogen, Incorporated, Cambridge, Massachusetts 02142
  • Woodcock, Stephen A. Department of Immunology and Inflammation, Biogen, Incorporated, Cambridge, Massachusetts 02142
  • Qian, Fang Department of Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
  • Batten, Marcel Garvan Institute of Medical Research, St. Vincent's Hospital, Darlinghurst NSW 2010, Australia
  • Madry, Christine Institut National de la Santé et de la Recherche Médicale U131, 92140 Clamart, France
  • Richard, Yolande Institut National de la Santé et de la Recherche Médicale U131, 92140 Clamart, France
  • Benjamin, Christopher D. Department of Immunology and Inflammation, Biogen, Incorporated, Cambridge, Massachusetts 02142
  • Browning, Jeffrey L. Department of Immunology and Inflammation, Biogen, Incorporated, Cambridge, Massachusetts 02142
  • Tsapis, Andreas Institut National de la Santé et de la Recherche Médicale U131, 92140 Clamart, France
  • Tschopp, Jurg Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
  • Ambrose, Christine Department of Molecular Genetics, Biogen, Incorporated, Cambridge, Massachusetts 02142
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  • 2000-7-3
Published in:
  • Journal of Experimental Medicine. - Rockefeller University Press. - 2000, vol. 192, no. 1, p. 129-136
Immunology
Immunology and Allergy
English The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor–triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population.
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  • English
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bronze
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https://sonar.rero.ch/global/documents/19598
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