Journal article
A randomized double-blind controlled study of 6 months of oral nutritional supplementation with arginine and omega-3 fatty acids in HIV-infected patients. Swiss HIV Cohort Study.
- Pichard C Division of Nutrition, University Hospital, Geneva, Switzerland.
- Sudre P
- Karsegard V
- Yerly S
- Slosman DO
- Delley V
- Perrin L
- Hirschel B
- 1998-02-10
Published in:
- AIDS (London, England). - 1998
Acquired Immunodeficiency Syndrome
Adult
Arginine
Body Composition
Body Weight
CD4 Lymphocyte Count
CD8-Positive T-Lymphocytes
Dietary Supplements
Double-Blind Method
Eating
Electric Impedance
Fatty Acids, Omega-3
Feeding Behavior
Female
HIV Infections
Humans
Lymphocyte Count
Male
Minerals
Outpatients
Patient Compliance
Quality of Life
Receptors, Tumor Necrosis Factor
Viremia
Vitamins
Weight Gain
English
OBJECTIVE
To evaluate the effects of an oral nutritional supplement enriched with two potentially immunostimulant compounds (arginine and omega-3 fatty acids) on the changes in food intake, body composition, immune parameters and viraemia in HIV-infected outpatients.
DESIGN
Six-month prospective randomized double-blind controlled study.
SETTING
University hospital outpatient nutrition clinic.
PATIENTS
Sixty-four HIV-infected outpatients with CD4 lymphocyte count > or = 10O x 10(6)/l.
INTERVENTION
All patients received a daily oral nutritional supplement (606 kcal supplemented with vitamins, trace elements and minerals). In addition, half of the patients were randomized to receive 7.4 g arginine plus 1.7 g omega-3 fatty acids.
MAIN OUTCOME MEASURES
Disease progression measured by AIDS-defining events, CD4 and CD8 lymphocyte counts, viraemia, tumour necrosis factor soluble receptors, nutritional status determined by anthropometric, bioelectrical impedance and dietetic assessment.
RESULTS
Fifty-five patients completed the protocol. Compliance with and tolerance of oral nutritional supplement during the 6-month period was excellent. In both groups of patients the following were found: total energy intake was transiently increased and then returned to baseline level; nitrogen/energy intake ratio was increased throughout the study; gain of body weight and fat mass were approximately 2 and 1kg, respectively, over 6 months, and were similar in both groups. In addition, CD4 and CD8 lymphocyte counts, viraemia, tumour necrosis factor soluble receptors remained statistically unchanged and were similar in both groups.
CONCLUSIONS
Enrichment of an oral nutritive supplement with arginine and omega-3 fatty acids did not improve immunological parameters. However, body weight increased in both groups.
To evaluate the effects of an oral nutritional supplement enriched with two potentially immunostimulant compounds (arginine and omega-3 fatty acids) on the changes in food intake, body composition, immune parameters and viraemia in HIV-infected outpatients.
DESIGN
Six-month prospective randomized double-blind controlled study.
SETTING
University hospital outpatient nutrition clinic.
PATIENTS
Sixty-four HIV-infected outpatients with CD4 lymphocyte count > or = 10O x 10(6)/l.
INTERVENTION
All patients received a daily oral nutritional supplement (606 kcal supplemented with vitamins, trace elements and minerals). In addition, half of the patients were randomized to receive 7.4 g arginine plus 1.7 g omega-3 fatty acids.
MAIN OUTCOME MEASURES
Disease progression measured by AIDS-defining events, CD4 and CD8 lymphocyte counts, viraemia, tumour necrosis factor soluble receptors, nutritional status determined by anthropometric, bioelectrical impedance and dietetic assessment.
RESULTS
Fifty-five patients completed the protocol. Compliance with and tolerance of oral nutritional supplement during the 6-month period was excellent. In both groups of patients the following were found: total energy intake was transiently increased and then returned to baseline level; nitrogen/energy intake ratio was increased throughout the study; gain of body weight and fat mass were approximately 2 and 1kg, respectively, over 6 months, and were similar in both groups. In addition, CD4 and CD8 lymphocyte counts, viraemia, tumour necrosis factor soluble receptors remained statistically unchanged and were similar in both groups.
CONCLUSIONS
Enrichment of an oral nutritive supplement with arginine and omega-3 fatty acids did not improve immunological parameters. However, body weight increased in both groups.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1097/00002030-199801000-00007
- PMID 9456255
- Persistent URL
- https://sonar.rero.ch/global/documents/195300
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