Journal article
A case report of Clarkson's disease: If you don't know it, you'll miss it.
- Bonadies N Department of Internal Medicine, University Hospital Bern, 3010 Bern, Switzerland.
- Baud P
- Peter HJ
- Buergi U
- Mueller BU
- 2006-07-26
Published in:
- European journal of internal medicine. - 2006
English
The systemic capillary leak syndrome (SCLS), also known as Clarkson's disease, is a rare disorder characterized by paroxysmal capillary hyperpermeability with a shift of plasma fluid from the intravascular to the interstitial space. A 35-year-old previously healthy woman was admitted with rapidly developing hypovolemic shock syndrome, rhabdomyolysis, and diffuse edema. Laboratory analysis revealed a severe hemoconcentration, renal insufficiency, and paraproteinemia. After exclusion of infection, allergy, burning or drug-induced conditions, the clinical presentation was consistent with the diagnosis of SCLS. Though this is a rare entity, the substantial morbidity and mortality associated with it necessitate the physician's awareness in order to provide timely therapy. This report is meant to enhance awareness of SCLS.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.ejim.2005.12.011
- PMID 16864014
- Persistent URL
- https://sonar.rero.ch/global/documents/192314
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