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Interplay between cardiac function and heart development.
Journal article

Interplay between cardiac function and heart development.

  • Andrés-Delgado L Development of the Epicardium and Its Role during Regeneration Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII), Melchor Fernández Almagro 3, 28029 Madrid, Spain.
  • Mercader N Development of the Epicardium and Its Role during Regeneration Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII), Melchor Fernández Almagro 3, 28029 Madrid, Spain; Institute of Anatomy, University of Bern, Bern, Switzerland. Electronic address: nadia.mercader@ana.unibe.ch.
  • 2016-03-09
Published in:
  • Biochimica et biophysica acta. - 2016
Blood and pericardial flow
Cardiac development
Mechanosensing
Mechanotransduction
Mouse
Zebrafish
Action Potentials
Adaptation, Physiological
Age Factors
Animals
Coronary Circulation
Heart
Heart Diseases
Hemodynamics
Humans
Mechanotransduction, Cellular
Morphogenesis
Myocytes, Cardiac
Regeneration
Stress, Mechanical
English Mechanotransduction refers to the conversion of mechanical forces into biochemical or electrical signals that initiate structural and functional remodeling in cells and tissues. The heart is a kinetic organ whose form changes considerably during development and disease. This requires cardiomyocytes to be mechanically durable and able to mount coordinated responses to a variety of environmental signals on different time scales, including cardiac pressure loading and electrical and hemodynamic forces. During physiological growth, myocytes, endocardial and epicardial cells have to adaptively remodel to these mechanical forces. Here we review some of the recent advances in the understanding of how mechanical forces influence cardiac development, with a focus on fluid flow forces. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.rero.ch/global/documents/173265
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