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Modes of presentation of chemical neoantigens to the immune system.
Journal article

Modes of presentation of chemical neoantigens to the immune system.

  • Pichler WJ Division of Allergology, Clinic for Rheumatology and Clinical Immunology/Allergology, Inselspital, CH-3010 Bern, Switzerland. werner.pichler@insel.ch
  • 2002-12-31
Published in:
  • Toxicology. - 2002
Animals
Antigens
Drug Hypersensitivity
Haptens
Humans
Pharmaceutical Preparations
Predictive Value of Tests
Receptors, Immunologic
T-Lymphocytes
English The immune system can interact with small molecular compounds like drugs. Drugs are not only immunogenic because of their chemical reactivity, but also because they may bind in a labile way to MHC-molecules and fit into available T-cell receptors. This seems to be sufficient to stimulate T-cells. Such structural features of a drug have to be considered in the evaluation of drug hypersensitivity reactions and should be taken into account in predictive drug allergy testing.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.rero.ch/global/documents/172254
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