Journal article
Serial EEG findings in sporadic and iatrogenic Creutzfeldt-Jakob disease.
- Wieser HG Department of Neurology, Zürich University Hospital, Zurich, Switzerland. hgwepi@neurol.unizh.ch
- Schwarz U
- Blättler T
- Bernoulli C
- Sitzler M
- Stoeck K
- Glatzel M
- 2004-10-07
Published in:
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. - 2004
Adult
Aged
Creutzfeldt-Jakob Syndrome
Delta Rhythm
Electrodes, Implanted
Electroencephalography
Equipment Contamination
Female
Humans
Iatrogenic Disease
Male
Time Factors
English
OBJECTIVE
To study temporal and spatial development of EEG patterns in sporadic and iatrogenic Creutzfeldt-Jakob disease patients.
METHODS
Temporal and spatial development of EEG patterns in 4 patients with sporadic Creutzfeldt-Jakob disease and 2 patients with iatrogenic Creutzfeldt-Jakob disease due to implantation of contaminated brain depth electrodes were investigated. A total of 56 EEGs were analyzed, over time spans ranging from 1272 to 3 days prior to death.
RESULTS
Frontal intermittent rhythmical delta activity (FIRDA) was seen at early timepoints in 4/6 patients and might represent an early EEG pattern that is associated, with human prion diseases. EEG patterns associated with CJD are sensitive to midazolam. Initial EEG changes were seen at the site of prion exposure in iatrogenic Creutzfeldt-Jakob disease patients, before they could be observed at distant sites, suggesting that prion disease was initiated at the site of prion exposure.
CONCLUSIONS
Serial EEG recordings are a valuable tool not only in the early diagnosis of sporadic CJD, but also in the determination of prion exposure in iatrogenic Creutzfeldt-Jakob disease.
SIGNIFICANCE
FIRDA occur at an early stage of CJD and are progressively replaced by the classical PSWC. The EEG patterns of CJD are sensitive to midazolam. The initial EEG changes in iatrogenic CJD are seen at the site of prion exposure.
To study temporal and spatial development of EEG patterns in sporadic and iatrogenic Creutzfeldt-Jakob disease patients.
METHODS
Temporal and spatial development of EEG patterns in 4 patients with sporadic Creutzfeldt-Jakob disease and 2 patients with iatrogenic Creutzfeldt-Jakob disease due to implantation of contaminated brain depth electrodes were investigated. A total of 56 EEGs were analyzed, over time spans ranging from 1272 to 3 days prior to death.
RESULTS
Frontal intermittent rhythmical delta activity (FIRDA) was seen at early timepoints in 4/6 patients and might represent an early EEG pattern that is associated, with human prion diseases. EEG patterns associated with CJD are sensitive to midazolam. Initial EEG changes were seen at the site of prion exposure in iatrogenic Creutzfeldt-Jakob disease patients, before they could be observed at distant sites, suggesting that prion disease was initiated at the site of prion exposure.
CONCLUSIONS
Serial EEG recordings are a valuable tool not only in the early diagnosis of sporadic CJD, but also in the determination of prion exposure in iatrogenic Creutzfeldt-Jakob disease.
SIGNIFICANCE
FIRDA occur at an early stage of CJD and are progressively replaced by the classical PSWC. The EEG patterns of CJD are sensitive to midazolam. The initial EEG changes in iatrogenic CJD are seen at the site of prion exposure.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.clinph.2004.05.032
- PMID 15465434
- Persistent URL
- https://sonar.rero.ch/global/documents/16661
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