Systemic and cellular reflections on ageing and the circadian oscillator: a mini-review.
- Brown SA Department of Pharmacology and Toxicology, University of Zurich, Switzerland. steven.brown @ pharma.uzh.ch
- Pagani L
- Cajochen C
- Eckert A
- 2010-10-29
Published in:
- Gerontology. - 2011
Adaptation, Biological
Aged
Aging
Animals
Biological Evolution
Cellular Senescence
Chronobiology Discipline
Chronotherapy
Circadian Clocks
Circadian Rhythm
Humans
English
From circulation to digestion to excretion, a circadian clock synchronizes most aspects of mammalian physiology with the solar day. During normal ageing, this daily coordination gradually erodes, and during pathological ageing such erosion is exacerbated. Recent experiments suggest that therapies aimed at sustaining circadian function increase quality of life in elderly patients. Hence, a better understanding of the interactions between the circadian clock and ageing - at both cellular and systemic levels - could lead to direct benefits for aged individuals.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1159/000320673
- PMID 20980722
- Persistent URL
- https://sonar.rero.ch/global/documents/165677
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