GRADE guidelines: 22. The GRADE approach for tests and strategies-from test accuracy to patient-important outcomes and recommendations.

• Schünemann HJ Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada; Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada; McMaster GRADE Centre, Michael DeGroote Cochrane Canada Centre, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada. Electronic address: schuneh@mcmaster.ca.
• Mustafa RA Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada; Department of Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
• Brozek J Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada; Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada; McMaster GRADE Centre, Michael DeGroote Cochrane Canada Centre, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada.
• Santesso N Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada; McMaster GRADE Centre, Michael DeGroote Cochrane Canada Centre, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada.
• Bossuyt PM Clinical Epidemiology and Biostatistics and Bioinformatics Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O.Box 227001100 DE, Amsterdam, The Netherlands.
• Steingart KR Cochrane Infectious Diseases Group, Liverpool School of Tropical Medicine, Liverpool, L3 5QA UK.
• Leeflang M Clinical Epidemiology and Biostatistics and Bioinformatics Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O.Box 227001100 DE, Amsterdam, The Netherlands.
• Lange S Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen/Institute for Quality and Efficiency in Health Care (IQWiG), Im Mediapark 8, Köln, 50670 Cologne, Germany.
• Trenti T Azienda Ospedaliera Universitaria e Azienda USL di Modena, Nuovo Ospedale S. Agostino Estense, Via Giardini 1355, Modena, 41126 Italy.
• Langendam M Clinical Epidemiology and Biostatistics and Bioinformatics Academic Medical Center, University of Amsterdam, Meibergdreef 9, P.O.Box 227001100 DE, Amsterdam, The Netherlands.
• Scholten R Cochrane Netherlands/Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P.O. Box 85500, Utrecht, 3508 GA The Netherlands.
• Hooft L Cochrane Netherlands/Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P.O. Box 85500, Utrecht, 3508 GA The Netherlands.
• Murad MH Division of Preventive Medicine, Mayo Clinic, 200 1st, ST, SW, Rochester, MN 55902, USA.
• Jaeschke R Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada; Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada.
• Rutjes A Clinical Trial Unit (CTU) Bern, Institute of Primary Health Care; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
• Singh J Medicine Service, VA Medical Center, Birmingham, AL, USA; Department of Medicine, University of Alabama at Birmingham, 510, 20th Street South, Birmingham, FOT805B AL, USA.
• Helfand M Oregon Evidence-based Practice Center, Oregon Health & Science University, Portland VA Medical Center, Portland, OR, USA.
• Glasziou P CREBP, Faculty Health Science & Medicine, Bond University, Gold Coast, Queensland 4229, Australia.
• Arevalo-Rodriguez I Clinical Biostatistics Unit, Ramón y Cajal Hospital (IRYCIS), Madrid, Spain; Division of Research, Fundación Universitaria de Ciencias de la Salud, Hospital de San José, Hospital Infantil de San José, Bogotá, Colombia.
• Akl EA Department of Internal Medicine, American University of Beirut, Riad-El-Solh Beirut, Beirut, 1107 2020 Lebanon.
• Deeks JJ Test Evaluation Research Group, Institute of Applied Health Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT UK.
• Guyatt GH Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada; Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S4K1, Canada.

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Diagnosis

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Tests

GRADE Approach

Humans

Outcome Assessment, Health Care