Permeability and penicillin-binding protein alterations in Salmonella muenchen: stepwise resistance acquired during beta-lactam therapy.
- Bellido F Département de Microbiologie, Centre Médical Universitaire de Genève, Switzerland.
- Vladoïanu IR
- Auckenthaler R
- Suter S
- Wacker P
- Then RL
- Pechère JC
- 1989-07-01
Published in:
- Antimicrobial agents and chemotherapy. - 1989
Anti-Bacterial Agents
Autoradiography
Bacterial Outer Membrane Proteins
Bacterial Proteins
Carrier Proteins
Drug Resistance, Microbial
Electrophoresis, Polyacrylamide Gel
Hexosyltransferases
Humans
Infant
Male
Membrane Proteins
Microbial Sensitivity Tests
Muramoylpentapeptide Carboxypeptidase
Penicillin-Binding Proteins
Peptidyl Transferases
Permeability
Plasmids
Salmonella
Salmonella Infections
beta-Lactams
English
A patient with Salmonella muenchen sepsis was unsuccessfully treated with ampicillin. During therapy, four strains that showed stepwise ampicillin resistance and affected other beta-lactams and unrelated antibiotics were isolated sequentially. Resistance was caused by decreased outer membrane permeability associated with diminished expression of porin OmpF. Furthermore, the most resistant isolate overproduced the PBP 3 target molecule.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1128/aac.33.7.1113
- PMID 2782862
- Persistent URL
- https://sonar.rero.ch/global/documents/152325
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