Thiourea-based fluorescent chemosensors for aqueous metal ion detection and cellular imaging.
- Vonlanthen M Department of Chemistry, University of Zurich , Zurich CH-8057, Switzerland.
- Connelly CM
- Deiters A
- Linden A
- Finney NS
- 2014-06-25
Published in:
- The Journal of organic chemistry. - 2014
Fluorescent Dyes
HeLa Cells
Humans
Ions
Mercury
Metals
Molecular Imaging
Spectrometry, Fluorescence
Thiourea
Water
English
We describe three significant advances in the use of thioureas as reporting elements for metal-responsive fluorescent chemosensors. First, on the basis of the crystal structure of a chemosensor analogue, we provide a deeper understanding of the details of the thiourea coordination environment. Second, we describe a new generation of chemosensors with higher affinities for Zn(2+) and Cd(2+) than were observed for earlier probes, expanding the scope of this type of probe beyond Hg(2+) detection. Third, we show that a thiourea-based chemosensor can be employed for fluorescence microscopy imaging of Hg(2+) ion concentrations in living mammalian cells.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1021/jo500710g
- PMID 24957917
- Persistent URL
- https://sonar.rero.ch/global/documents/151324
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