Journal article
Minocycline-induced lupus. A systematic review.
- Schlienger RG Division of Clinical Pharmacology, University Hospital, Basel, Switzerland. rschlienger@uhbs.ch
- Bircher AJ
- Meier CR
- 2000-06-01
Published in:
- Dermatology (Basel, Switzerland). - 2000
Adolescent
Adult
Age of Onset
Anti-Bacterial Agents
Antibodies, Antinuclear
Female
Humans
Lupus Erythematosus, Systemic
Male
Middle Aged
Minocycline
English
BACKGROUND
Minocycline has increasingly been associated with different adverse auto-immune reactions including drug-induced lupus.
OBJECTIVE
To identify the scope of minocycline-induced lupus and to characterise its typical features.
METHODS
Comprehensive Medline and Embase search of the English and non-English literature for case reports of minocycline-induced lupus.
RESULTS
We included 57 cases of minocycline-induced lupus (mean age +/- SD at onset: 21.6+/-8.6 years, median time of exposure: 19 months, range 3 days to 6 years). All patients showed the clinical features of polyarthralgia/polyarthritis often accompanied by liver abnormalities. Twelve patients had evidence of dermatological manifestations (i.e rash, livedo reticularis, oral ulceration, subcutaneous nodules, alopecia). The ANA test was positive in all patients.
CONCLUSION
Long-term exposure to minocycline may be associated with drug-induced lupus. Baseline and periodic liver function and ANA tests accompanied by appropriate clinical monitoring are suggested for patients receiving long-term minocycline therapy.
Minocycline has increasingly been associated with different adverse auto-immune reactions including drug-induced lupus.
OBJECTIVE
To identify the scope of minocycline-induced lupus and to characterise its typical features.
METHODS
Comprehensive Medline and Embase search of the English and non-English literature for case reports of minocycline-induced lupus.
RESULTS
We included 57 cases of minocycline-induced lupus (mean age +/- SD at onset: 21.6+/-8.6 years, median time of exposure: 19 months, range 3 days to 6 years). All patients showed the clinical features of polyarthralgia/polyarthritis often accompanied by liver abnormalities. Twelve patients had evidence of dermatological manifestations (i.e rash, livedo reticularis, oral ulceration, subcutaneous nodules, alopecia). The ANA test was positive in all patients.
CONCLUSION
Long-term exposure to minocycline may be associated with drug-induced lupus. Baseline and periodic liver function and ANA tests accompanied by appropriate clinical monitoring are suggested for patients receiving long-term minocycline therapy.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1159/000018387
- PMID 10828631
- Persistent URL
- https://sonar.rero.ch/global/documents/15013
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