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Aqueous dynamics in experimental ab externo trabeculectomy.
Journal article

Aqueous dynamics in experimental ab externo trabeculectomy.

  • 2000-06-01
Published in:
  • Ophthalmic research. - 2000
Animals
Anterior Chamber
Aqueous Humor
Glaucoma
Humans
In Vitro Techniques
Intraocular Pressure
Swine
Trabecular Meshwork
Trabeculectomy
English PURPOSE
This study assessed the decrease in intraocular pressure (IOP), the residual outflow resistance of the trabeculum and the filtration site by histology in enucleated pig and human eyes after ab externo trabeculectomy.


METHOD
Measurement of the resistance to aqueous outflow was performed using the constant pressure method before and after ab externo trabeculectomy.


RESULTS
The outflow facility was 0.31 +/- 0.13 microl/min/mm Hg in pig eyes and 0.24 +/- 0.08 microl/min/mm Hg in human eyes before surgery, and 79.0 +/- 47. 6 microl/min/mm Hg in pig eyes and 6.33 +/- 6.67 microl/min/mm Hg in human eyes after ab externo trabeculectomy. On histological examinations the aqueous outflow pathway was seen to be at the level of the residual trabecular meshwork.


CONCLUSION
This study showed that ab externo trabeculectomy significantly lowers IOP and improves outflow facility in enucleated pig and human eyes.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.rero.ch/global/documents/137185
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