The control of branching morphogenesis.
- Iber D Department of Biosystems Science and Engineering (D-BSSE), ETH Zürich, Basel, Switzerland.
- Menshykau D
- 2013-09-06
Published in:
- Open biology. - 2013
branching
computational modelling
in silico organogenesis
Animals
Computer Simulation
Humans
Kidney
Lung
Male
Mammary Glands, Human
Models, Biological
Morphogenesis
Pancreas
Prostate
Salivary Glands
English
Many organs of higher organisms are heavily branched structures and arise by an apparently similar process of branching morphogenesis. Yet the regulatory components and local interactions that have been identified differ greatly in these organs. It is an open question whether the regulatory processes work according to a common principle and how far physical and geometrical constraints determine the branching process. Here, we review the known regulatory factors and physical constraints in lung, kidney, pancreas, prostate, mammary gland and salivary gland branching morphogenesis, and describe the models that have been formulated to analyse their impacts.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1098/rsob.130088
- PMID 24004663
- Persistent URL
- https://sonar.rero.ch/global/documents/134643
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