Journal article
Role of reactive oxygen species (ROS) in apoptosis induction.
- Simon HU Department of Pharmacology, University of Bern, Switzerland.
- Haj-Yehia A
- Levi-Schaffer F
- 2001-03-21
Published in:
- Apoptosis : an international journal on programmed cell death. - 2000
English
Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1023/a:1009616228304
- PMID 11256882
- Persistent URL
- https://sonar.rero.ch/global/documents/129351
Statistics
Document views: 33
File downloads: