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Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.
Journal article

Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.

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  • 1994-07-01
Published in:
  • Science (New York, N.Y.). - 1994
Cell Line
Chromosome Mapping
Chromosomes, Human, Pair 16
Fibroblasts
Gene Expression Regulation
Genes, MHC Class II
Histocompatibility Antigens Class II
Humans
Interferon-gamma
Models, Genetic
Nuclear Proteins
RNA, Messenger
Trans-Activators
Transfection
Tumor Cells, Cultured
English Major histocompatibility complex (MHC) class II genes are expressed constitutively in only a few cell types, but they can be induced in the majority of them, in particular by interferon-gamma (IFN-gamma). The MHC class II transactivator gene CIITA is defective in a form of primary MHC class II deficiency. Here it is shown that CIITA expression is controlled and induced by IFN-gamma. A functional CIITA gene is necessary for class II induction, and transfection of CIITA is sufficient to activate expression of MHC class II genes in class II-negative cells in the absence of IFN-gamma. CIITA is therefore a general regulator of both inducible and constitutive MHC class II expression.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.rero.ch/global/documents/127420
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