Ion-Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules.
- Kruve A Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.
- Caprice K Department of Organic Chemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211, Geneva 4, Switzerland.
- Lavendomme R Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
- Wollschläger JM Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.
- Schoder S Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.
- Schröder HV Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.
- Nitschke JR Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
- Cougnon FBL Department of Organic Chemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211, Geneva 4, Switzerland.
- Schalley CA Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.
- 2019-06-08
Published in:
- Angewandte Chemie (International ed. in English). - 2019
English
A rapid screening method based on traveling-wave ion-mobility spectrometry (TWIMS) combined with tandem mass spectrometry provides insight into the topology of interlocked and knotted molecules, even when they exist in complex mixtures, such as interconverting dynamic combinatorial libraries. A TWIMS characterization of structure-indicative fragments generated by collision-induced dissociation (CID) together with a floppiness parameter defined based on parent- and fragment-ion arrival times provide a straightforward topology identification. To demonstrate its broad applicability, this approach is applied here to six Hopf and two Solomon links, a trefoil knot, and a [3]catenate.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1002/anie.201904541
- PMID 31173448
- Persistent URL
- https://sonar.rero.ch/global/documents/103550
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