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Studies toward the Total Synthesis of the Marine Macrolide Salarin C.
Journal article

Studies toward the Total Synthesis of the Marine Macrolide Salarin C.

  • Schrof R Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences , ETH Zürich , Vladimir-Prelog-Weg 4 , CH-8093 Zürich , Switzerland.
  • Altmann KH Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences , ETH Zürich , Vladimir-Prelog-Weg 4 , CH-8093 Zürich , Switzerland.
  • 2018-11-27
Published in:
  • Organic letters. - 2018
Physical and Theoretical Chemistry
Organic Chemistry
Biochemistry
English A convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described. The macrolactone core of 3 was assembled by Suzuki coupling between alkyl iodide 9 and vinyl iodide 8 and Shiina macrolactonization as key transformations. All macrocyclic intermediates were found to be of low stability.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.rero.ch/global/documents/101077
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