Scheeren, Ferenc A. Nagasawa, Maho Weijer, Kees Cupedo, Tom Kirberg, Jörg Legrand, Nicolas Spits, Hergen 2008 <jats:p>IgM+IgD+CD27+ B cells from peripheral blood have been described as circulating marginal zone B cells. It is still unknown when and where these cells develop. These IgM+IgD+CD27+ B cells exhibit somatic hypermutations (SHMs) in their B cell receptors, but the exact nature of the signals leading to induction of these SHMs remains elusive. Here, we show that IgM+IgD+CD27+ B cells carrying SHMs are observed during human fetal development. To examine the role of T cells in human IgM+IgD+CD27+ B cell development we used an in vivo model in which Rag2−/−γC−/− mice were repopulated with human hematopoietic stem cells. Using Rag2−/−γC−/− mice on a Nude background, we demonstrated that development and induction of SHMs of human IgM+IgD+CD27+ B cells can occur in a T cell–independent manner.</jats:p> application/pdf https://sonar.rero.ch/global/documents/1857 eng info:eu-repo/semantics/altIdentifier/doi/10.1084/jem.20070447 info:eu-repo/semantics/altIdentifier/issn/1540-9538 info:eu-repo/semantics/openAccess Journal of Experimental Medicine. - Rockefeller University Press. - 2008, vol. 205, no. 9, p. 2033-2042 Immunology Immunology and Allergy T cell–independent development and induction of somatic hypermutation in human IgM+IgD+CD27+ B cells http://purl.org/coar/resource_type/c_6501